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Le président Talon entame des concertations avec l'UP-R

24 Heures au Bénin - lun, 20/10/2025 - 12:16

Le président Patrice Talon a engagé une série de concertations politiques avec la direction de l'Union Progressiste - le Renouveau (UP- R), dans le cadre des élections communales de 2025.

Depuis samedi, le chef de l'État passe en revue, département par département, les propositions de candidatures du parti Union Progressiste - le Renouveau (UP-R) aux élections communales de 2026, selon des sources bien informées.

Ce dimanche 19 octobre, les discussions se sont poursuivies jusque tard dans la soirée avec les représentants de l'Atacora, de la Donga, du Borgou, des Collines, de l'Ouémé et du Plateau.

Ces échanges, selon plusieurs sources, visent à “apprécier, examiner et harmoniser” les positionnements sur les listes dans le cadre des élections communales de 2026.

Le chef de l'Etat clôturera ce lundi cette série de consultations avec la délégation de l'Atlantique. Cette dernière étape marquera la décision finale sur les candidats à présenter dans les circonscriptions électorales.

Catégories: Afrique

4 milliards FCFA pour 150.000 ménages vulnérables via GBESSOKÊ

24 Heures au Bénin - lun, 20/10/2025 - 12:16

Le Programme de Filets de Protection Sociale Productifs “GBESSOKÊ”, une initiative du gouvernement béninois pour soutenir les ménages les plus vulnérables et leur offrir de véritables opportunités de relèvement économique, a été lancé jeudi 16 octobre 2025.

Porté par le ministère des Affaires sociales et de la Microfinance, le Programme de Filets de Protection Sociale Productifs “GBESSOKÊ ambitionne de soutenir 150.000 ménages, soit environ 1 million de Béninois, grâce à une combinaison de transferts monétaires et de mesures d'accompagnement vers l'autonomie économique.

La phase pilote lancée dans 12 communes réparties dans les 12 départements du Bénin touche déjà 20.621 personnes, dont 85 % de femmes.

Deux premiers versements mensuels de 208 millions FCFA chacun ont été effectués en septembre et octobre 2025.

Au total, près de 4 milliards FCFA sont mobilisés pour cette première phase, sur une période de neuf mois.

À cela s'ajoute une enveloppe additionnelle de 50.000 FCFA par bénéficiaire prévue au 6ᵉ et 9ᵉ mois pour soutenir les AGR. Soit 2,08 milliards FCFA d'aides productives supplémentaires.

La ministre des Affaires Sociales et de la Microfinance, Véronique Tognifodé, a salué une rupture avec les politiques sociales ponctuelles. « Le social devient un outil de dignité et d'autonomisation », a-t-elle affirmé.

Le programme prévoit aussi l'appui à 10.000 ménages sinistrés par les inondations.

Le représentant résident de la Banque mondiale, partenaire du programme, a salué « l'ambition et la rigueur » des autorités béninoises, assurant du soutien continu de l'institution.

Selon des femmes bénéficiaires, les premiers versements du programme leur ont permis de faire d'importantes activités : lancement de petits commerces, achat de vivres, scolarisation des enfants. Pour beaucoup, ces aides sont « un souffle nouveau ».

Catégories: Afrique

"Gari Sohoui" de Savalou et l'huile "Azimi d'Agonlin" désormais protégés

24 Heures au Bénin - lun, 20/10/2025 - 12:16

Le Bénin enregistre deux nouvelles Indications Géographiques Protégées (IGP). Le "Gari Sohoui" de Savalou et l'huile "Azimi d'Agonlin" ont été officiellement certifiés par l'Organisation Africaine de la Propriété Intellectuelle (OAPI).

"Gari Sohoui" de Savalou et l'huile "Azimi d'Agonlin" ; ces deux produits agricoles du Bénin rejoignent l'ananas "Pain de sucre", déjà reconnu. Ils deviennent les 22e et 23e Indications géographiques protégées (IGP) par l'Organisation Africaine de la Propriété Intellectuelle (OAPI).

Une reconnaissance dont les enregistements ont été publiés au bulletin officiel de la propriété industrielle de l'OAPI le 30 septembre 2025 sous le numéro 02-2025.

La ministre de l'Industrie et du Commerce, Shadiya Assouman, a reçu le 18 octobre 2025, les certificats des mains de l'OAPI. « Cette reconnaissance ouvre la voie à de nouveaux marchés », a-t-elle déclaré.

L'IGP protège les noms des produits dans les 17 États membres de l'OAPI. Leur usage est désormais strictement encadré.

« Ces noms ne peuvent plus être utilisés pour des produits qui ne viennent pas des zones d'origine », a rappelé Michel Gonomy, expert IGP à l'OAPI. Il évoque des sanctions sévères en cas de contrefaçon.

Le processus de labellisation a duré 6 ans.

Pour Denis Bohoussou, directeur général de l'OAPI, cette certification est un levier de développement. Elle valorise la qualité des produits, leur ancrage géographique et les savoir-faire locaux.
M. M.

Catégories: Afrique

Spanischer Rüstungskonzern Indra wirbt für stärkere Kooperation in Europa

Euractiv.de - lun, 20/10/2025 - 12:15
Anstelle einer Führungsrolle einzelner Staaten oder Konzerne plädiert Indra-Chef José Vicente de los Mozos für Co-Leads – also geteilte Verantwortung und eine breitere industrielle Beteiligung.
Catégories: Europäische Union

Le Maroc sacré champion du monde U20

24 Heures au Bénin - lun, 20/10/2025 - 12:15

Le Maroc a écrit une nouvelle page de son histoire sportive. Les jeunes Lions de l'Atlas ont remporté, dimanche 19 octobre 2025, au Chili, la Coupe du monde U20, un premier sacre mondial salué dans tout le royaume.

Dès le coup de sifflet final de la rencontre Maroc#Argentine (2-0) joué, dimache au Chili, des scènes de liesse ont éclaté dans les villes marocaines telles que Rabat, Casablanca, Fès, Marrakech, Laâyoune ou encore Tanger.

Des milliers de supporters, drapeaux en main, ont envahi les rues pour chanter, danser et célébrer leurs héros. L'atmosphère était électrique, empreinte de fierté et d'unité nationale.

Lors de la cérémonie officielle, en présence d'officiels de la FIFA et de nombreuses personnalités, SM le roi Mohammed VI a salué une victoire « d'excellence », fruit de la « persévérance, du talent et de la discipline » de cette jeunesse marocaine.

Ce succès fait du Maroc l'une des rares nations africaines à avoir remporté cette compétition, après le Ghana en 2009.
Pour le souverain, il s'agit d'un exploit « qui honore tout le continent africain et consacre le travail accompli pour le développement du sport national ».

Avec ce sacre, le football marocain confirme son essor continu sur la scène internationale, porté par une génération ambitieuse et inspirante.

La Colombie termine troisième et la France quatrième de cette édition 2025.

M. M.

Catégories: Afrique

Décès de THIOMBIANO/OUOBA Miaba Pascaline : Remerciements

Lefaso.net (Burkina Faso) - lun, 20/10/2025 - 12:00

 Sa Majesté OUNTAMBA Roi du Gulmu ;

La grande famille Yabinpargou à Tikonti, secteur 9 de Fada ;

 La grande famille THIOMBIANO Damondougou André à Fada N'Gourma, Ouagadougou, Bobo-Dioulasso, en France et alliés ;

 La grande famille OUOBA

Kpana Défaye à Diapagpa/Tapoa,Fada N'Gourma, Ouagadougou, Bobo-Dioulasso et alliés ;

Monsieur THIOMBIANO André Félix et enfants.

Remercient tous ceux qui, de près ou de loin ont manifesté leur compassion à travers des soutiens multiples et multiformes à leur endroit lors du rappel à Dieu de leur épouse, mère,grande-mère, soeur , belle-mère, belle-sœur, tante, fille et petite-fille,

Madame THIOMBIANO/OUOBA Miaba Pascaline, décès survenu le jeudi 02/10/2025 à l'hôpital Yalgado de Ouagadougou de suite d'une courte maladie et son enterrement le 07/10/2025 au cimetière de Tabtenga.
Les familles THIOMBIANO et OUOBA vous traduisent toute leur reconnaissance et souhaitent que le Dieu miséricordieux et Tout-puissant rende à chacun au centuple le mérite de ses bienfaits.

« L'éternel est près de ceux qui ont le cœur brisé. Et il sauve ceux qui ont l'esprit dans l'abattement » Psaume 34 : 18

Catégories: Afrique

AMENDMENTS 1 - 436 - Draft report Human Rights and Democracy in the world and the European Union’s policy on the matter – annual report 2025 - PE778.262v02-00

AMENDMENTS 1 - 436 - Draft report Human Rights and Democracy in the world and the European Union’s policy on the matter – annual report 2025
Committee on Foreign Affairs
Francisco Assis

Source : © European Union, 2025 - EP
Catégories: European Union

EU-Mitgliedstaaten kurz vor Einigung auf LNG-Importverbot aus Russland

Euractiv.de - lun, 20/10/2025 - 11:34
Laut Ratsentwurf soll das LNG-Verbot ab 2026 greifen – Spotkäufe enden am 1. Januar, Kurzzeitverträge im Juni, und ab 2028 sind auch langfristige Gaslieferungen aus Russland verboten.
Catégories: Europäische Union

Press release - Press briefing on this week’s plenary session

European Parliament - lun, 20/10/2025 - 11:14
European Parliament’s spokespersons will hold a last-minute briefing on the 20 - 23 October plenary session today at 16.30.

Source : © European Union, 2025 - EP
Catégories: European Union

Press release - Press briefing on this week’s plenary session

Europäisches Parlament (Nachrichten) - lun, 20/10/2025 - 11:14
European Parliament’s spokespersons will hold a last-minute briefing on the 20 - 23 October plenary session today at 16.30.

Source : © European Union, 2025 - EP
Catégories: Europäische Union

Press release - Press briefing on this week’s plenary session

Európa Parlament hírei - lun, 20/10/2025 - 11:14
European Parliament’s spokespersons will hold a last-minute briefing on the 20 - 23 October plenary session today at 16.30.

Source : © European Union, 2025 - EP

DRAFT REPORT on a European Parliament recommendation to the Council, the Commission and the Vice-President of the Commission / High Representative of the Union for Foreign Affairs and Security Policy concerning an enhanced EU-Canada cooperation in the...

DRAFT REPORT on a European Parliament recommendation to the Council, the Commission and the Vice-President of the Commission / High Representative of the Union for Foreign Affairs and Security Policy concerning an enhanced EU-Canada cooperation in the light of the current geopolitical context, including the threats to Canada’s economic stability and sovereignty
Committee on Foreign Affairs
Tobias Cremer

Source : © European Union, 2025 - EP
Catégories: European Union

Le Conseil avance sur le prochain budget de l’UE alors que le Parlement est dans l’impasse

Euractiv.fr - lun, 20/10/2025 - 10:33

Euractiv a obtenu un projet de document du Conseil de l’UE montrant que les capitales poursuivent leurs travaux sur la proposition de cadre fiancier pluriannuel (CFP) 2028-2034 de la Commission européenne. Les eurodéputés, eux, restent divisés sur le futur budget.

The post Le Conseil avance sur le prochain budget de l’UE alors que le Parlement est dans l’impasse appeared first on Euractiv FR.

Catégories: Union européenne

Rapporteur | 20. Oktober

Euractiv.de - lun, 20/10/2025 - 10:08
Willkommen bei Rapporteur! Jeden Tag liefern wir Ihnen die wichtigsten Nachrichten und Hintergründe aus der EU- und Europapolitik. Need-to-knows: Brüssel: EU-Diplomaten beraten über das 19. Sanktionspaket gegen Russland, nachdem Österreich sein Veto aufgehoben hat. Luxemburg: Außenminister sprechen über Ukraine, den Nahen Osten und die Spannungen in Georgien. Amsterdam: Schwedische Parteispitzen streiten beim Kongress der Sozialdemokraten […]
Catégories: Europäische Union

Bosnie-Herzégovine : la Republika Srpska fait volte-face et annule ses lois sécessionnistes

Courrier des Balkans / Bosnie-Herzégovine - lun, 20/10/2025 - 10:03

C'est une volte-face inattendue, dont les États-Unis s'attribuent la paternité. L'Assemblée nationale de la Republika Srpska a annulé ses propres lois jugées « anti-Dayton » et désigné Ana Trišić Babić, une proche de Milorad Dodik, comme présidente par intérim de l'entité.

- Le fil de l'Info / , , , ,
Catégories: Balkans Occidentaux

Women’s Leadership at the Heart of Disaster Risk Reduction

Africa - INTER PRESS SERVICE - lun, 20/10/2025 - 10:01

Disasters touch everyone but are not felt equally. Women often take longer to rebuild their livelihoods after a crisis and may face additional barriers in accessing the resources to facilitate a quicker recovery. Credit:: UNDP Nigeria

By Raquel Lagunas and Ronald Jackson
NEW YORK, Oct 20 2025 (IPS)

Climate and environmental challenges are hitting harder and more often, reshaping people’s lives around the world. While disasters touch everyone, their impacts are not felt equally. The most marginalized, especially women and girls, are too often the first to suffer and the last to recover.

Social roles, discrimination and economic inequalities amplify the risks women face in times of crisis and undermine communities’ capacity to rebuild their livelihoods. Placing gender equality at the heart of disaster risk reduction (DDR) isn’t only a matter of fairness, but a key to a more resilient future for all.

UNDP is working with partners to translate this vision into action, by advancing equality and inclusion at every stage of disaster risk reduction, from preparedness to response and recovery. Drawing on our experience we see five powerful ways women’s leadership and meaningful participation can strengthen communities’ ability to withstand and recover from future shocks.

Women’s leadership strengthens resilience 

At UNDP, we actively open doors for women to shape decisions and policies at every level, from local committees to national platforms. We draw on their expertise and perspectives while amplifying the leadership and innovation they already bring to building resilience.

By investing in women’s ideas and supporting their initiatives, we help unlock solutions that ripple across communities, strengthening food security, sustaining livelihoods, and driving progress on every front.

In Bosnia and Herzegovina, the Feminist Coalition for Climate Justice, supported by UNDP, has improved working conditions for over 75,000 women, trained 1,500 women officials in energy and climate management, and opened new opportunities for women-led enterprises.

Meanwhile, in Chad, with support from France through the Global Women, Peace and Security initiative, women’s cooperatives have combined climate-smart agriculture, solar irrigation, and early warning systems to reduce flood risks and support recovery, showing how women-led approaches can strengthen risk reduction measures, preparedness, livelihoods and peacebuilding, even in fragile settings.

Unpaid care responsibilities grow during crises, as disasters disrupt schools, health systems and basic services, placing even greater pressure on women. Credit: UNDP Haiti

Resilience relies on care

Resilience depends on care, and women shoulder more than three-quarters of the world’s unpaid caregiving, supporting children, older adults, people with disabilities and entire communities. These responsibilities grow during crises, as disasters disrupt schools, health systems and basic services, placing even greater pressure on women.

Recognizing and prioritizing care in disaster management, through early warning systems, safe spaces, and continuity of essential services, helps protect lives and speeds up recovery for everyone.

UNDP supports countries to integrate care into disaster and climate strategies. In Honduras, Cuba, Belize and Guatemala, a geo-referenced care mapping tool helps to identify gaps in childcare, eldercare and disability-inclusive services. In Honduras, this analysis helped authorities identify ‘care deserts’ in flood- and landslide-prone areas, prioritize safe-space upgrades, and ensure that care continuity is factored into evacuation and rehabilitation plans.

In Ukraine, the ‘Mommy in the Shelter’ initiative transformed a basement into a child-friendly refuge activated during air raids, linking early warning with ongoing maternal and childcare support, even in acute conflicts.

Gender data means better planning and better response

Good planning starts with good data. Without information that is broken down by sex, age, and disability, disaster risk reduction policies can miss the unique needs and strengths of different parts of the community, especially for marginalized groups. High-quality gender disaggregated data helps ensure that strategies are targeted, effective and inclusive.

Last year, UNDP increased sex-disaggregated data and gender analysis in 20 countries affected by crisis. Cuba, Indonesia, Maldives, Myanmar, Samoa and Yemen developed early warning systems that strengthen women’s engagement and leadership.

In Ethiopia, disaster risk reduction measures helped women-headed households recover from landslides, while in Armenia, inclusive risk assessments led by women fed directly into local development and recovery plans.

With strong data, broken down by sex, age and disability, disaster risk reduction policies can address the specific needs of different parts of societies, including marginalized groups. Credit: UNDP Türkiye

Institutions equipped with gender capacities are better equipped for resilience

Resilient communities start with resilient institutions. When organizations, from national authorities managing risks, to local risk committees, embed gender considerations into their policy, planning and programming, good intentions turn to real progress, moving from rhetoric to routine.

Guatemala’s national disaster risk management authority set a new standard by earning UNDP’s Gender Equality Seal for Public Institutions. This means gender mandates, data and participation, including for Indigenous women, are woven into local risk management. Stronger institutions like these are better equipped to meet people’s needs and build lasting resilience.

Breaking down barriers, building resilience

Despite real progress, gaps remain. Gender equality is still too often sidelined across disaster, climate, humanitarian and development efforts. Let’s work together to make women’s leadership, care and inclusion central to every plan and policy.

Together, we can:

    • Make women’s leadership non-negotiable in DRR decision making and financing. 
    • Direct more capital to women’s resilience, including through risk financing, social protection, and support to women-led enterprises. 
    • Centre care in preparedness and continuity plans so alerts translate into protection for caregivers, children, older persons and persons with disabilities.
    • Strengthen national and local institutional capacities to apply a gender lens to how risks are managed, from efforts to prevent, prepare, respond to and recover from hazardous events. 
    •  When these measures are consistently applied, communities everywhere will be better able to face challenges and confidently bounce back.

Raquel Lagunas is Global Director of Gender Equality, UNDP; Ronald Jackson is Head of the Disaster Risk Reduction, Recovery for Building Resilience, UNDP

Source: UN Development Programme (UNDP)

IPS UN Bureau

 


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Catégories: Africa

Les Vingt-Sept s’orientent vers une interdiction totale du gaz russe d’ici 2028

Euractiv.fr - lun, 20/10/2025 - 09:38

Malgré les réserves exprimées en dernière minute par la France, l’Italie et l’Espagne, liées à des questions de sécurité juridique et au nouveau mécanisme de contrôle des cargaisons de GNL, un consensus semble se dessiner parmi les États membres. Les Vingt-Sept devraient entériner une échéance fixée à 2028 pour mettre fin à toute importation de gaz russe.

The post Les Vingt-Sept s’orientent vers une interdiction totale du gaz russe d’ici 2028 appeared first on Euractiv FR.

Catégories: Union européenne

Viktor Orbán immobilise Bruxelles

Euractiv.fr - lun, 20/10/2025 - 09:30

Bienvenue dans Rapporteur. Je suis Eddy Wax au Luxembourg, avec Nicoletta Ionta à Bruxelles. Vous avez une info à nous communiquer ? Écrivez-nous, nous lisons tous les messages. À savoir : Bruxelles : les diplomates de l’UE se réunissent pour discuter du 19ᵉ paquet de sanctions contre la Russie après la levée du veto de […]

The post Viktor Orbán immobilise Bruxelles appeared first on Euractiv FR.

Catégories: Union européenne

XDR-TB Drug Trial Participants Continue to Celebrate its Success

Africa - INTER PRESS SERVICE - lun, 20/10/2025 - 09:22

Tsholofelo Msimango pictured at her home in Brakpan, near Johannesburg. Credit: TB Alliance/Jonathan Torgovnik

By Ed Holt
BRATISLAVA, Oct 20 2025 (IPS)

When Tsholofelo Msimango joined a small trial of a new drug regimen for tuberculosis (TB) treatment a decade ago, she had no idea whether the medicines she was about to be given would help her.

But having already spent six months in hospital after developing extensively drug-resistant TB (XDR-TB), the most lethal form of the disease, which at the time was barely curable—three-quarters of people with XDR-TB were thought to die before they even received a diagnosis and only a third of those who got treatment survived—Msimango decided she had little to lose.

“I had my doubts, of course, as to whether it would have any success,” she tells IPS.  “But to be honest, at that point all I could think about was that it might make me better, that I might be able to get out of hospital and go home. I was ready to take that chance. I’m glad I did. That trial saved my life—I am sure of it,” she says.

Msimango, who was 21 at the time, from Brakpan in South Africa, was one of 109 participants in the Nix-TB trial of a new drug regimen that ran across three sites in the country between 2015 and 2017.

Until then, typical treatment for the most severe drug-resistant forms of TB would involve patients taking daily doses of a potent cocktail of pills—dozens in some cases—as well as injections for sometimes as long as two years.

The side effects of such regimens can be horrific—deafness, kidney failure and psychosis have been reported—and there are high rates of treatment drop-out, leading not only to a worsening of the patient’s own condition but also to the further spread of the worst strains of the disease among communities.

The Nix-TB trial tested an all-oral six-month drug regimen, which was a combination of the drugs pretomanid, bedaquiline and linezolid (BPaL).

Its results—the regimen had a 90 percent treatment success rate —werehailed as groundbreaking by experts, and the trial proved to be a landmark moment in the fight against the world’s most deadly infectious disease.

Msimango says that until she joined the trial, she had been taking “lots of pills and having injections.” The latter, she says, had stopped working against the disease.

But not long into the trial, she noticed a change. Before the trial she had struggled to keep weight on because of her illness and treatment.

“It was when I started to gain weight that I began to think that the treatment was working. We had check-ups, including for weight, every week and when I saw myself putting on weight, I knew then that I was getting better,” she says.

By the end of the trial, she says she felt like a different person.

Tests showed she was free of TB.

“Of course I was excited about the fact that I could finally stop taking medicines, and because I was then healthy and free of TB and could live a normal life again, but I was also excited about the fact that I was going to be able to finally leave hospital after a year and go home.

“I had already been in hospital for seven months before the trial started, and then another six months for the trial, and it was hard being away from home for a year. The hospital was a long way from where I lived so it was very hard for my mother to come and visit me and bring me things,” she says.

Tsholofelo Msimango and her son at her home in Brakpan, near
Johannesburg. Credit: TB Alliance/Jonathan Torgovnik

But while now healthy and free of TB, the disease has continued to play a large role in Msimango’s life.

She decided she wanted to help others affected by TB. Today she is a TB community advocate and educator and helps to recruit people for medical studies.

“I would recommend to anyone that if they get the chance to take part in a study like the one that I got to take part in, that they should go for it,” she says.

Now a mother to a young boy, she says she speaks to him about what she went through and about TB so that he understands about the disease and the risks it poses.

“I talk to my son about what happened to me, why I was in hospital and why I now work in the TB community. I tell my son and his friends about TB and what can be done to stop its spread and how they can help, for instance, by covering their mouths when they cough,” she says.

“Actually, I tell my story a lot because I hope it might help other people,” she adds.

Another participant in the trial, Bongiswa Mdaka, says the same.

“I talk to people all the time about TB and my experience with it—I’m very open about it. If I see someone has been coughing for more than two weeks, I tell them about the disease and about getting tested and treated as early as possible,” she told IPS.

Speaking from her home in Vereeniging, Gauteng, Mdaka, who was 27 when she started the trial, said that, like Msimango, it changed her life.

“The trial was a lifesaver for me. It not only changed my life but saved it. It gave me a second chance. Ten years ago, before the trial, the situation for people with XDR-TB was not good. I was diagnosed with MDR-TB and when my condition continued to get worse, I was hospitalized. I was in the hospital for three days and they told me that no, I don’t have MDR-TB; I have XDR-TB, the worst I could have. It was like hearing a death sentence.

Tsholofelo Msimango’s late mother, Zeldah Nkosi. She says her mother was a “pillar of support” during her time when she had TB. Credit: TB Alliance

“So when the people doing the trial came to me, it seemed like a godsend. I had no major expectations—I just hoped that I would get better. Today I am healthy and free of TB. I’m strong. I have a family and a normal life. Life is good,” she said.

Speaking to experts who were involved in the trial, it becomes clear that going into it, no one knew how important it would eventually prove to be in the future of TB treatment.

Dr. Pauline Howell managed the patients during the Nix-TB trial at the Sizwe Tropical Diseases Hospital in Johannesburg, where Msimango was a patient.

“Prior to the Nix trial we knew that treatment was too long, too toxic, worked in less than half of people afflicted with TB, and in those diagnosed with XDR TB (per the pre-2021 definition), only 20 percent were still alive after 5 years. I was still junior in clinical trials in 2015, but it was clear to everyone that knew anything about XDR-TB that replacing the extended treatment, which included at least 6 months of injectables, and all the other drugs (the kitchen sink approach) with just three drugs made us more than a little anxious,” she told IPS.

But like many of the trial’s participants, she saw relatively quickly how well the treatment was working.

“When trial participants started telling newly admitted patients about this trial and brought them to the research site before we had had a chance to speak with them, that was speaking loudly. When certain patients, who had been admitted for over two years, were suddenly starting to respond to TB treatment and culture convert, it was wonderful to celebrate with them, Howell, who is now Clinical Research Site Leader at Sizwe Tropical Disease Hospital, said. “When patients were relocating from the Eastern Cape to Gauteng just to get access to the trial, we knew this was the treatment we’d also want for ourselves and our loved ones.”

“There are definitely a few [trial participants] who may not have survived without this treatment, but for the majority, they were able to get back to their lives faster, potentially cause fewer onward infections and suffer less loneliness and other repercussions of having drug-resistant TB,” she added.

However, while the trial had an immediate effect on its participants, its results, which suggested the enormous potential of the regimen, paved the way for BPaL to revolutionize TB treatment.

“I had no idea that this trial would be the first step towards changing the treatment for drug-resistant tuberculosis worldwide,” Howell said.

“It’s good to remember that although TB is deadly, it is curable, and the side effects of the BPaL/M regimen are common but predictable and manageable. A decade ago, patients put an end to rental agreements for their homes, quit their jobs, told their partners to move on and their families took out funeral policies. These days, patients sit in front of me and say, ‘I have been here for two weeks already! I need to get home and back to my life’. It makes my head spin how much has changed, partially due to the Nix trial,” she added.

In 2022, the World Health Organization (WHO) endorsed BPaL with or without another drug, moxifloxacin (M), and BPaL(M) is today the preferred treatment option for drug-resistant TB.

According to data from the TB Alliance, the nonprofit group that developed pretomanid, BPaL and BPaL-based regimens, they treat about 75 percent of the overall number of drug-resistant TB cases treated annually. This number is projected to soon reach 90 percent.

Meanwhile, the group says, the regimens have already saved more than 11,000 lives and USD 100 million for health systems globally and by 2034 are expected to save an additional 192,000 lives and health systems almost USD 1.3 billion.

In some countries classed as having high-burden TB epidemics, they have already altered the TB landscape significantly.

“In South Africa, which adopted the BPaL/M guidelines in Sep 2023, we are seeing a single-digit percentage lost to follow-up for the first time in the history of our TB programme,” she says.

But the regimen’s potential may be in danger of not being fully fulfilled as richer nations cut foreign aid budgets, impacting funding that has traditionally helped support disease and other healthcare programmes in poor countries.

“The eternal challenge with TB is how closely it is tied to lack of access, poverty, substance use, being undomiciled and general lack of funding to overcome these challenges… Unfortunately, as long as there is poverty and lack of access, political will and funding, TB will continue to live side by side with us,” said Howell.

“Some people now can’t get their medications because of these cuts,” said Msimango. “They’re costing people’s lives.”

Note: This article is brought to you by IPS Noram in collaboration with INPS Japan and Soka Gakkai International in consultative status with ECOSOC.

IPS UN Bureau Report


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Before the successful Nix-TB trial, which took place in South Africa from 2015 to 2017, patients with extensively drug-resistant TB (XDR-TB) had to follow a complicated treatment plan for the deadliest form of the disease.
Catégories: Africa

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