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XDR-TB Drug Trial Participants Continue to Celebrate its Success

Africa - INTER PRESS SERVICE - lun, 20/10/2025 - 09:22

Tsholofelo Msimango pictured at her home in Brakpan, near Johannesburg. Credit: TB Alliance/Jonathan Torgovnik

By Ed Holt
BRATISLAVA, Oct 20 2025 (IPS)

When Tsholofelo Msimango joined a small trial of a new drug regimen for tuberculosis (TB) treatment a decade ago, she had no idea whether the medicines she was about to be given would help her.

But having already spent six months in hospital after developing extensively drug-resistant TB (XDR-TB), the most lethal form of the disease, which at the time was barely curable—three-quarters of people with XDR-TB were thought to die before they even received a diagnosis and only a third of those who got treatment survived—Msimango decided she had little to lose.

“I had my doubts, of course, as to whether it would have any success,” she tells IPS.  “But to be honest, at that point all I could think about was that it might make me better, that I might be able to get out of hospital and go home. I was ready to take that chance. I’m glad I did. That trial saved my life—I am sure of it,” she says.

Msimango, who was 21 at the time, from Brakpan in South Africa, was one of 109 participants in the Nix-TB trial of a new drug regimen that ran across three sites in the country between 2015 and 2017.

Until then, typical treatment for the most severe drug-resistant forms of TB would involve patients taking daily doses of a potent cocktail of pills—dozens in some cases—as well as injections for sometimes as long as two years.

The side effects of such regimens can be horrific—deafness, kidney failure and psychosis have been reported—and there are high rates of treatment drop-out, leading not only to a worsening of the patient’s own condition but also to the further spread of the worst strains of the disease among communities.

The Nix-TB trial tested an all-oral six-month drug regimen, which was a combination of the drugs pretomanid, bedaquiline and linezolid (BPaL).

Its results—the regimen had a 90 percent treatment success rate —werehailed as groundbreaking by experts, and the trial proved to be a landmark moment in the fight against the world’s most deadly infectious disease.

Msimango says that until she joined the trial, she had been taking “lots of pills and having injections.” The latter, she says, had stopped working against the disease.

But not long into the trial, she noticed a change. Before the trial she had struggled to keep weight on because of her illness and treatment.

“It was when I started to gain weight that I began to think that the treatment was working. We had check-ups, including for weight, every week and when I saw myself putting on weight, I knew then that I was getting better,” she says.

By the end of the trial, she says she felt like a different person.

Tests showed she was free of TB.

“Of course I was excited about the fact that I could finally stop taking medicines, and because I was then healthy and free of TB and could live a normal life again, but I was also excited about the fact that I was going to be able to finally leave hospital after a year and go home.

“I had already been in hospital for seven months before the trial started, and then another six months for the trial, and it was hard being away from home for a year. The hospital was a long way from where I lived so it was very hard for my mother to come and visit me and bring me things,” she says.

Tsholofelo Msimango and her son at her home in Brakpan, near
Johannesburg. Credit: TB Alliance/Jonathan Torgovnik

But while now healthy and free of TB, the disease has continued to play a large role in Msimango’s life.

She decided she wanted to help others affected by TB. Today she is a TB community advocate and educator and helps to recruit people for medical studies.

“I would recommend to anyone that if they get the chance to take part in a study like the one that I got to take part in, that they should go for it,” she says.

Now a mother to a young boy, she says she speaks to him about what she went through and about TB so that he understands about the disease and the risks it poses.

“I talk to my son about what happened to me, why I was in hospital and why I now work in the TB community. I tell my son and his friends about TB and what can be done to stop its spread and how they can help, for instance, by covering their mouths when they cough,” she says.

“Actually, I tell my story a lot because I hope it might help other people,” she adds.

Another participant in the trial, Bongiswa Mdaka, says the same.

“I talk to people all the time about TB and my experience with it—I’m very open about it. If I see someone has been coughing for more than two weeks, I tell them about the disease and about getting tested and treated as early as possible,” she told IPS.

Speaking from her home in Vereeniging, Gauteng, Mdaka, who was 27 when she started the trial, said that, like Msimango, it changed her life.

“The trial was a lifesaver for me. It not only changed my life but saved it. It gave me a second chance. Ten years ago, before the trial, the situation for people with XDR-TB was not good. I was diagnosed with MDR-TB and when my condition continued to get worse, I was hospitalized. I was in the hospital for three days and they told me that no, I don’t have MDR-TB; I have XDR-TB, the worst I could have. It was like hearing a death sentence.

Tsholofelo Msimango’s late mother, Zeldah Nkosi. She says her mother was a “pillar of support” during her time when she had TB. Credit: TB Alliance

“So when the people doing the trial came to me, it seemed like a godsend. I had no major expectations—I just hoped that I would get better. Today I am healthy and free of TB. I’m strong. I have a family and a normal life. Life is good,” she said.

Speaking to experts who were involved in the trial, it becomes clear that going into it, no one knew how important it would eventually prove to be in the future of TB treatment.

Dr. Pauline Howell managed the patients during the Nix-TB trial at the Sizwe Tropical Diseases Hospital in Johannesburg, where Msimango was a patient.

“Prior to the Nix trial we knew that treatment was too long, too toxic, worked in less than half of people afflicted with TB, and in those diagnosed with XDR TB (per the pre-2021 definition), only 20 percent were still alive after 5 years. I was still junior in clinical trials in 2015, but it was clear to everyone that knew anything about XDR-TB that replacing the extended treatment, which included at least 6 months of injectables, and all the other drugs (the kitchen sink approach) with just three drugs made us more than a little anxious,” she told IPS.

But like many of the trial’s participants, she saw relatively quickly how well the treatment was working.

“When trial participants started telling newly admitted patients about this trial and brought them to the research site before we had had a chance to speak with them, that was speaking loudly. When certain patients, who had been admitted for over two years, were suddenly starting to respond to TB treatment and culture convert, it was wonderful to celebrate with them, Howell, who is now Clinical Research Site Leader at Sizwe Tropical Disease Hospital, said. “When patients were relocating from the Eastern Cape to Gauteng just to get access to the trial, we knew this was the treatment we’d also want for ourselves and our loved ones.”

“There are definitely a few [trial participants] who may not have survived without this treatment, but for the majority, they were able to get back to their lives faster, potentially cause fewer onward infections and suffer less loneliness and other repercussions of having drug-resistant TB,” she added.

However, while the trial had an immediate effect on its participants, its results, which suggested the enormous potential of the regimen, paved the way for BPaL to revolutionize TB treatment.

“I had no idea that this trial would be the first step towards changing the treatment for drug-resistant tuberculosis worldwide,” Howell said.

“It’s good to remember that although TB is deadly, it is curable, and the side effects of the BPaL/M regimen are common but predictable and manageable. A decade ago, patients put an end to rental agreements for their homes, quit their jobs, told their partners to move on and their families took out funeral policies. These days, patients sit in front of me and say, ‘I have been here for two weeks already! I need to get home and back to my life’. It makes my head spin how much has changed, partially due to the Nix trial,” she added.

In 2022, the World Health Organization (WHO) endorsed BPaL with or without another drug, moxifloxacin (M), and BPaL(M) is today the preferred treatment option for drug-resistant TB.

According to data from the TB Alliance, the nonprofit group that developed pretomanid, BPaL and BPaL-based regimens, they treat about 75 percent of the overall number of drug-resistant TB cases treated annually. This number is projected to soon reach 90 percent.

Meanwhile, the group says, the regimens have already saved more than 11,000 lives and USD 100 million for health systems globally and by 2034 are expected to save an additional 192,000 lives and health systems almost USD 1.3 billion.

In some countries classed as having high-burden TB epidemics, they have already altered the TB landscape significantly.

“In South Africa, which adopted the BPaL/M guidelines in Sep 2023, we are seeing a single-digit percentage lost to follow-up for the first time in the history of our TB programme,” she says.

But the regimen’s potential may be in danger of not being fully fulfilled as richer nations cut foreign aid budgets, impacting funding that has traditionally helped support disease and other healthcare programmes in poor countries.

“The eternal challenge with TB is how closely it is tied to lack of access, poverty, substance use, being undomiciled and general lack of funding to overcome these challenges… Unfortunately, as long as there is poverty and lack of access, political will and funding, TB will continue to live side by side with us,” said Howell.

“Some people now can’t get their medications because of these cuts,” said Msimango. “They’re costing people’s lives.”

Note: This article is brought to you by IPS Noram in collaboration with INPS Japan and Soka Gakkai International in consultative status with ECOSOC.

IPS UN Bureau Report


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Excerpt:

Before the successful Nix-TB trial, which took place in South Africa from 2015 to 2017, patients with extensively drug-resistant TB (XDR-TB) had to follow a complicated treatment plan for the deadliest form of the disease.
Catégories: Africa

Thousands of grief-stricken mourners attend Raila Odinga's funeral

BBC Africa - ven, 17/10/2025 - 20:15
Thousands of mourners attend the state funeral of former Prime Minister Raila Odinga in Nairobi.
Catégories: Africa

Chile Aims for Sustainable Port Expansion – VIDEO

Africa - INTER PRESS SERVICE - ven, 17/10/2025 - 20:01

By Orlando Milesi
SAN ANTONIO, Chile, Oct 17 2025 (IPS)

Maritime transport is key for Chile, which has 34 free trade agreements with countries and blocs of nations, one of the broadest trade networks in the world with access to over 86% of the global gross domestic product (GDP).

In 2024, this South American country surpassed US$100 billion in exports for the first time, mostly of copper, forest products, fresh fruits, fish, and organic foods. In turn, it imported US$78.025 billion, mostly diesel oil, clothing, accessories, and footwear.

Faced with growing trade, experts predict enormous port demand by 2036 in this long and narrow South American country squeezed between the Andes and the Pacific Ocean.



To avoid a collapse in 10 years, the San Antonio Outer Port project will triple the capacity of Chile’s main route for the exit and entry of products.

San Antonio currently handles 29% of the tonnage of maritime foreign trade, 34% of exports, and 71% of Chile’s imports by value.

The high agricultural and mining production from Chile’s central area, which contributes 59% of the country’s GDP and is home to 63% of its 19.7 million inhabitants, passes through this port.

The outer port will allow for the movement of six million containers thanks to two new port terminals, 1,730 meters long and 450 meters wide, with eight new berthing fronts for state-of-the-art container ships.

The total estimated investment for the project is US$4.45 billion, which will be financed by the government and by international companies applying for concessions.

The first months of 2026 will be key for awarding the dredging works, the construction of the breakwater, the protective infrastructure for the new port, and for learning the authorities’ decision on the environmental impact of the San Antonio Outer Port works.

Measures will be taken to mitigate that impact, including the protection of two wetlands located on port land and support for the work of fishermen in nearby coves. To decarbonize, the port project will also use energy produced from renewable sources.

San Antonio, 110 kilometers west of Santiago and south of the historic port of Valparaiso, which it has surpassed in relevance, is aiming for a revival by promoting the largest port infrastructure project in Chile’s history.

It currently provides 10,200 direct jobs to port workers with an average monthly income of US$1,110.

San Antonio aims to consolidate its ninth place among the largest ports in Latin America and expand its role in the movement of cargo to and from Asia and the Americas.

Its managers also seek to show that infrastructure development can be harmonized with the protection and improvement of environmental conditions through a project that is a model of sustainability.

Catégories: Africa

The moment Madagascar's new president was sworn in

BBC Africa - ven, 17/10/2025 - 15:50
Colonel Michael Randrianirina is sworn in as the new president of Madagascar at a ceremony in the capital.
Catégories: Africa

Connecting the Dots: Policy Shifts, Realities and Lessons

Africa - INTER PRESS SERVICE - ven, 17/10/2025 - 06:38

A female merchant was crossing a bustling street in Hanoi, Vietnam. Despite economic development over five decades, development gaps in Asia and the Pacific remained. Credit: Unsplash/Jeremy Stewardson

By Sudip Ranjan Basu
BANGKOK Thailand, Oct 17 2025 (IPS)

The Asia-Pacific region has long served as a springboard for transforming socio-economic implementation gaps into development opportunities. With the 2030 deadline for the Sustainable Development Goals fast approaching, policymakers are stepping up efforts to translate policy announcements into tangible impacts.

Looking back since 1970s, the region’s development trajectory has been shaped by a series of crises that triggered transformative policy responses. By engaging strategic partnerships, countries in the region are well-positioned to promote shared prosperity for both people and the planet.

Anchoring crisis-driven policy shifts
In the 1970s, technological advances—particularly in agriculture—ushered in a new era. The introduction of high-yield crop varieties, known as the Green Revolution, boosted food production and rural incomes, laying the foundation for the emergence of a middle class. However, the decade also exposed vulnerabilities, as volatility in global commodity and energy prices exposed the risks of external shocks.

The 1980s brought further challenges. Rising oil prices and global interest rates strained national budgets across developing countries. The cost of servicing external debt crowded out investments in productive sectors, highlighting the risks of over-reliance on foreign aid.

The 1997 Asian financial crisis marked a watershed moment. Currency collapses, triggered capital flight and trade disruptions, leaving deep scars and prompting shifts in political governance and economic policy across the region.

By the early 2000s, optimism returned. Trade and investment surged, regional value chains expanded, and ICT-driven growth integrated economies more deeply into the global economy. Globalization was widely seen as a pathway to long-term prosperity.

Yet the 2008 global financial crisis shattered this euphoria. Inflation soared, investor confidence plummeted, and trade contracted.

Fast forward to the COVID-19 pandemic, which once again exposed lingering vulnerabilities: socio-economic inequality was deepened, jobs prospects dimmed, overdependence on supply chain became more pronounced, technological monopolies were revealed, and environmental fragility was clearly manifested. The pandemic reinforced the urgent need for adaptive policy frameworks.

These crisis episodes underscored the importance of coordinated policy action in an interconnected landscape, reinforcing the lesson that growth without adequate and shared outcomes is unsustainable.

Adjusting to changing socio-economic realities
The development journey has been marked by complexity and diversity. A comparative analysis over recent decades reveals recurring patterns: energy and food price volatility and tightening financial conditions have consistently tested policymakers. Rising interest rates in advanced economies have reignited debt concerns in developing countries, threatening economic stability and undermining progress.

Simultaneously, intensifying geopolitical competition is reshaping trade relationships, investment flows and technology transfers. Policymakers must navigate these shifts while advancing national development priorities and adapting to evolving dynamics.

These pressures have prompted to diversify its sources of economic growth and strategic engagements. Despite impressive achievements in social development, long-term stability and impact-driven outcomes hinge on governments’ ability to manage external shocks, anticipate risks, and promote cross-border economic cooperation and accelerate climate action.

Recent policy shifts signal a move toward structural transformation. Governments are spearheading industrialization, accelerating green energy transitions and pioneering sustainable financing mechanisms. This marks a shift from short-term crisis management to building medium- and long-term socio-economic progress.

The pandemic years further emphasised the need for adaptive policies—ones that can absorb unexpected shocks while maintaining progress toward stability.

Adapting through policy lessons
The development experience, particularly the least developed countries, the landlocked developing countries and small island developing States, offers valuable insights into building institutional capabilities and preventing future crises. Four strategic policy insights emerge:

Price stability matters: Volatile prices have repeatedly undermined development gains. Strategic foresight and balanced economic policy planning are essential to safeguard progress.
Fiscal buoyancy is critical: Excessive external borrowing has triggered past crises.

Creating fiscal space, mobilizing domestic resources, scaling blended finance and implementing coordinated debt management frameworks are vital for development.

Crisis preparedness requires coordination: The 1997 and 2008 crises showed that no country can respond effectively in isolation. Strengthening institutions is crucial for early warning systems, policy dialogue and coordinated action.

Sustainability is key to people-centred development: Climate change, socio-economic disparities and institutional inefficiencies pose long-term risks. Integrating sustainability into strategies and promoting technological transformation are no longer optional; they are imperative.

Turning points
The Asia-Pacific region’s development story is one of transition, and transformation. Connecting these turning points reveals a region that has consistently learned from its challenges and leveraged them to advance policy solutions.

The path ahead is promising, but policies must adapt to address shifting socio-economic dynamics, structural and climate change vulnerabilities, and emerging geopolitical realignments. These efforts must be anchored in regional cooperation, inclusive dialogue, and coordinated action, particularly through platforms such as ESCAP.

While governments play a central role, long-term progress will depend on the collective engagement of the private sector, academia, civil society and regional institutions. With strategic convergence, the Asia-Pacific region is well-positioned to overcome today’s uncertainty and shape a better future for all.

Sudip Ranjan Basu is Secretary of the Commission, ESCAP

IPS UN Bureau

 


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Catégories: Africa

Is the UN “Bloated, Unfocused, Outdated and Ineffective”?

Africa - INTER PRESS SERVICE - ven, 17/10/2025 - 06:19

By Thalif Deen
UNITED NATIONS, Oct 17 2025 (IPS)

The US hostility towards the UN is threatening to escalate, as a cash-starved world body is struggling for economic survival.

Addressing the UN’s Administrative and Budgetary Committee last week. Ambassador Jeff Bartos, U.S. Representative for U.N. Management and Reform said: “President Trump is absolutely right – the United Nations can be an important institution for solving international challenges, but it has strayed far from its original purpose”.

“Over 80 years, the UN has grown bloated, unfocused, too often ineffective, and sometimes even part of the problem. The UN’s failure to deliver on its core mandates is alarming and undeniable. “

The United States has been, by far, the largest funder of the UN since its founding. Based on the most recent scales of assessment, the United States provides more funding to the UN than 180 other nations combined, he pointed out.

“For the United States, the era of business as usual is over. During the Main Session, we will work with this Committee to achieve deeper cuts to wasteful spending and stronger accountability, with a relentless focus on results”.

The reductions already proposed in special political missions, the closure of unnecessary field offices, and the consolidation of executive offices, are the kind of decisions that must become the rule, not the exception.

Addressing the General Assembly last month, President Trump remarked: “What is the purpose of the United Nations? It’s not even coming close to living up to [its] potential.”

Dismissing the U.N. as an outdated, ineffective organization, he boasted: “I ended seven wars, dealt with the leaders of each and every one of these countries, and never a phone call from the United Nations offering to help in finalizing the deal.”

But UN’s political ineffectiveness is due primarily to the role played by the five veto-wielding permanent members of the Security Council—the US, UK, France, China and Russia–who are quick to protect their allies accused of human rights violations, war crimes or genocide.

Meanwhile, the U.S. has officially withdrawn or is in the process of withdrawing from the World Health Organization (WHO) and the UN Human Rights Council (UNHRC), and has ceased funding for the UN Relief and Works Agency (UNRWA) and from the UN Educational, Scientific and Cultural Organization (UNESCO).

Which triggers the question: what’s the fate and economic survival of the UN against an aggressive Trump administration?

Dr Alon Ben-Meir, a retired professor of international relations, most recently at the Center for Global Affairs at New York University (NYU), told IPS there is no other way to describe how the Trump administration is treating the UN other than self-defeating and detrimental to the US’s national interests, while substantially eroding America’s influence worldwide.

“It is hard to fathom how on earth Trump, who wants to ‘Make America Great Again,’ demonstrates such blatant hostility towards the only global organization in which the United States has, over the years, played such a pivotal and leading role that surpassed any other country since the UN’s creation in 1945.”

The statement by US Ambassador Bartos, he argued, is at best inaccurate and at worst totally wrong. It has never been a secret that the UN is overdue for significant reforms, beginning with the United Nations Security Council and many other UN agencies.

Dismissing the UN’s vital work on many fronts in one brush, however, and cutting humanitarian assistance on which millions in poor countries depend, or withdrawing from vital UN agencies, is unconscionable and highly damaging to the US’ leadership and national interests, he said.

“By what logic does the Trump administration justify its withdrawal from the World Health Organization (WHO), whose primary function is coordinating global health responses to crises such as pandemics, and setting international health standards?”

“One would think that the Trump administration would strongly support such an organization that serves US interests from a global health perspective and would only bolster the US influence by playing a significant role in improving its functions”.

How can the Trump administration explain its withdrawal from the UN Human Rights Council (UNHRC), which promotes and protects human rights worldwide through international cooperation?

By withdrawing from this organization, Trump forsakes any role that the US could play in preventing human rights abuses, which leads to fewer global checks on human rights abuses and weaker international standards.

Trump may care less about human rights violations, but how does withdrawing from such an organization serve the US’ overall national and global interests? he asked.

James E. Jennings, PhD, President, Conscience International, told IPS support for the United Nations organization is vital to global health and stability.,

“Those who have worked on the front lines of UN agencies’ responses to wars, natural disasters, and famines throughout the world cannot imagine the degree of inhumanity involved in taking food out of the mouths of babies, refusing to educate children, and letting disease and epidemics rage. This is not politics, it is bullying, and the world should see it for what it is”.

He said there is a pattern in Mr. Trump’s behavior that is easily exposed, Every one of his perceived enemies, as for example in the majority Democratic states of California and Illinois, he describes in the most terrible terms as crime-ridden and out of control.

“Within three days after he sends in ICE storm troopers to places like Washington DC who do nothing except display their muscle, suddenly that city or state is peaceable and under control.“

Trump brags that things are fine now in Portland, Chicago, and other such places, when no real change can be detected except that some normal citizens have been roughed up. Theatrics may win voters but does not in any way solve problems, said Dr Jennings.

The same technique can be observed on the international scene. After deprecating and sidelining UN peacemaking efforts, which go deeply into the issues, he makes phone calls to leaders of countries on the verge of hostilities and claims that he has ended seven wars, which is nonsense.

“By sidelining the UN, he simply wants to dominate it. With the US the biggest donor supporting the organization, there is a fair chance that he can succeed in bending it to his will unless national leaders, US citizens, and people everywhere are resolute in opposing his plans”, declared Dr Jennings.

IPS UN Bureau Report

 


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Catégories: Africa, Europäische Union

Police fire tear gas at crowds mourning former Kenyan prime minister

BBC Africa - jeu, 16/10/2025 - 19:55
Thousands of mourners fill the streets of Nairobi from the airport to the Kasarani Stadium to pay their respects.
Catégories: Africa

A Hungry World Knows No Borders

Africa - INTER PRESS SERVICE - jeu, 16/10/2025 - 16:31

By Dr Himanshu Pathak
HYDERABAD, India, Oct 16 2025 (IPS)

When crops fail, people move not by choice, but by necessity. As families are displaced by droughts and failed harvests, the pressures do not always stop at national boundaries. In short, hunger has become one of the most powerful forces shaping our century.

From the Sahel, the vast semi-arid belt stretching across Africa from Senegal to Sudan and the Horn of Africa to South Asia’s dry zones and Southeast Asia’s coastal farmlands, climate shocks are undermining food production and disrupting communities across the Global South.

In the Sahel, prolonged drought and poor harvests, among other factors, are driving migration north through Niger and Mali toward North Africa and, for some, across the Mediterranean.

Across South Asia, recurrent floods and heat stress have displaced millions in India and Bangladesh, while in Southeast Asia, rising seas are forcing coastal farmers and fishers inland.

These pressures are magnified by rapid population growth, especially in the Sahel, where the population is projected to more than double by 2050, placing immense strain on already limited arable land.

The same story is unfolding across the globe. In Central America’s drought-stricken Dry Corridor, years of crop failure are pushing families to leave their farms and migrate north in search of food and safety.

Safeguarding the right of people to remain where their families have lived for generations, now depends on enabling communities to produce more food from every hectare, even as conditions grow harsher.

This World Food Day (October 16), we must view food security not only as a humanitarian concern, but through the prism of peace and stability.

History shows that when people cannot feed their families, societies fracture and conflicts occur. The world’s most strategic investment today is in the hands that grow our food and not in walls or weapons.

By investing in climate resilient crops such as the drought and heat tolerant varieties developed by the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) and expanding access to scientific innovation and improved seeds, we enable communities to withstand climate shocks, secure their livelihoods, and remain in their traditional lands instead of being forced to migrate by a crisis not of their making.

These positive impacts are already visible, but they must now be scaled up dramatically to match the magnitude of the challenge.

The World Bank estimates that up to 216 million people could be forced to migrate within their own countries by 2050 as climate impacts intensify most of them in Africa and South Asia.
Investing in resilient food systems in the Global South is one of the most effective and humane strategies for ensuring regional and ultimately global stability.

The UNDP estimates that every dollar invested in sustainable agriculture today saves seven to ten dollars in humanitarian aid and migration management later.

At ICRISAT we witness this every day. Across Africa and Asia, we work with governments and communities to turn drylands, some of the harshest farming environments on Earth, into zones of opportunity.

In India’s Bundelkhand region, stretching across southern Uttar Pradesh and northern Madhya Pradesh our science-led watershed interventions have turned what were once parched and deserted wastelands into thriving, water-abundant croplands.

In Niger, climate-resilient seed systems are now transforming uncertainty into productivity. From drought-tolerant sorghum and pearl millet to digital tools that guide farmers on planting and water management, science is helping people stay and thrive where they are.

These few examples show that solutions exist. What is missing is scale and that requires more sustained investment.

Developed nations have both the capacity and the self-interest to act. Supporting food systems in the Global South should also be seen as insurance against instability.

A world where millions are forced to move in search of food and water will be a world without stability anywhere.

FAO’s 2025 World Food Day theme, “Hand in Hand for Better Food and a Better Future”, captures what this moment demands, a deeper investment in science that make a real difference, and genuine partnership.

Across the Global South, collaboration is already strengthening through the ICRISAT Center of Excellence for South-South Cooperation in Agriculture as nations share knowledge, seeds, and strategies to build resilience together.

Yet the North, too, has a vital role to play in recognition that hunger and instability anywhere can threaten prosperity everywhere.

The future of food security, peace, and climate resilience must be built together.
As the climate crisis tightens its hold, the world must choose, act now to strengthen the foundations of food and farming, or face the growing cost of displacement and unrest.

This World Food Day let us remember that peace, like harvests, depends on what we sow today.

Dr Himanshu Pathak Director General, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT)

IPS UN Bureau

 


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Excerpt:

Dr Himanshu Pathak is Director General, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT)
Catégories: Africa, Europäische Union

They Have Known Nothing but War—The Plight of Syria’s Out-of-School Children

Africa - INTER PRESS SERVICE - jeu, 16/10/2025 - 12:20

The community gets together to repair a school in the city of Saraqib, located south of Idlib, that was destroyed by bombing during the Assad regime. Credit: Sonia Al Ali/IPS

By Sonia Al Ali
IDLIB, Syria, Oct 16 2025 (IPS)

The war has deprived thousands of Syrian children of their right to education, especially displaced children in makeshift camps. Amidst difficult economic conditions and the inability of many families to afford educational costs, the future of these children is under threat.

Adel Al-Abbas, a 13-year-old boy from Aleppo, northern Syria, was forced to quit his education after being displaced from his city and moving to a camp on the Syrian-Turkish border. He says, “I was chasing my dream like any other child, but my family’s poverty and the harsh circumstances stood in my way and destroyed all my dreams.”

Adel had hoped to become an engineer, but he left school and gave up on his goal. He replaced books and pens with work tools to help his impoverished family secure life’s necessities. He adds, “We are living in extremely difficult conditions today; we can’t even afford food. So, I have to find a job to survive and help my family, especially after my father was hit by shrapnel in the head, which caused him a permanent disability.”

Adel’s mother is saddened by her son’s situation, saying to IPS, “We need the income my son brings in after my husband got sick and became unable to provide for our family. In any case, work is better than an education that is now useless after he’s been out of school for so long and has fallen behind his peers.”

Reem Al-Diri, an 11-year-old, left school after her family was displaced from rural Damascus to the city of Idlib in northern Syria. Explaining why, she speaks with a clear sense of regret: “I loved school very much and was one of the top students in my class, but my family decided I had to stop my education to help my mom with the housework.”

The young girl confirms that she watches children on their way to school every morning, and she wishes she could go with them to complete her education and become a teacher in the future.

Reem’s mother, Umayya Al-Khalid, justifies her daughter’s absence from school, saying, “After we moved to a camp on the outskirts of Idlib, the schools became far from where we live. We also suffer from a lack of security and the widespread kidnapping of girls. So, I feared for my daughter and preferred for her to stay at home.”

Causes of school dropout

Akram Al-Hussein, a school principal in Idlib, northern Syria, speaks about the school dropout crisis in the country.

“School dropouts are one of the most serious challenges facing society. The absence of education leads to an unknown future for children and for the entire community.”

Al-Hussein emphasizes that relevant authorities and the international community must exert greater efforts to support education and ensure it does not remain a distant dream for children who face poverty and displacement.

He adds, “The reasons and motivations for children dropping out of school vary, ranging from conditions imposed by war—such as killings, displacement, and forced conscription-to child labor and poverty. Other factors include frequent displacement and the child’s inability to settle in one place during the school year, as well as a general lack of parental interest in education and their ignorance of the risks of depriving a child of schooling.”

In this context, the Syria Response Coordinators team, a specialized statistics group in Syria, noted in a statement that the number of out-of-school children in Syria has reached more than 2.5 million, with northwestern Syria alone accounting for over 318,000 out-of-school children, with more than 78,000 of them living in displacement camps. Of this group, 85 percent are engaged in various occupations, including dangerous ones.

In a report dated June 12, 2024, the team identified the key reasons behind the widening school dropout crisis.

A shortage of schools relative to the population density, a shift towards private education, difficult economic conditions, a lack of local government laws to prevent children from entering the labor market, displacement and forced migration, and a marginalized education sector with insufficient support from both local and international humanitarian organizations are seen as the causes.

The team’s report warned that if this trend continues, it will lead to the emergence of an uneducated, illiterate generation. This generation will be consumers rather than producers, and as a result, these uneducated children will become a burden on society.

Initiatives to Restore Destroyed Schools

The destruction of schools in Syria has significantly contributed to the school dropout crisis. Throughout the years of war, schools were not spared from destruction, looting, and vandalism, leaving millions of children without a place to learn or in buildings unfit for education. However, with the downfall of the Assad regime, several initiatives have been launched to restore these schools. This is seen as an urgent and immediate necessity for building a new Syria.

Samah Al-Dioub, a school principal in the northern Syrian city of Maarat al-Nu’man, says, “Syria’s schools suffered extensive damage from both the earthquake and the bombings. We have collected funds from the city’s residents and are now working on rehabilitating the school, but the need is still immense and the costs are very high, especially with residents returning to the city.” She explained that their current focus is on surveying schools and prioritizing which ones need renovation the most.

Engineer Mohammad Hannoun, director of school buildings at the Syrian Ministry of Education, states that approximately 7,400 schools across Syria were either partially or completely destroyed. They have restored 156 schools so far.

Hannoun adds, “We are working to rehabilitate schools in all Syrian regions, aiming to equip at least one school in every village or city to welcome returning students. The Ministry of Education, along with local and international organizations and civil society, are all contributing to these restoration efforts.”

Hannoun points out that the extensive damage to school buildings harms both teachers and students. It leads to a lack of basic educational resources, puts pressure on the few schools that are still functional, and causes a large number of students to drop out, which ultimately impacts the quality of the educational process.

As part of their contingency plans, Hannoun explains that the ministry, in collaboration with partner organizations, intends to activate schools with the available resources to accommodate children returning from camps and from asylum countries. This effort is particularly focused on affected areas that have experienced massive waves of displacement.

The United Nations Children’s Fund (UNICEF) said in 2025, 16.7 million people, including 7.5 million children, are in need of humanitarian support in the country, with 2.45 million children out of school, and 2 million children are at risk of malnutrition.

The phenomenon of school dropouts has become a crisis threatening Syria’s children, who have been forced by circumstances to work to earn a living for their families. Instead of being in a classroom to build their futures, children are struggling to survive in an environment left behind by conflict and displacement.

 


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The Inescapable Reality the Israelis Must Face

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The UN General Assembly endorses New York Declaration on a two-State solution between Israel and Palestine. 12 September 2025. Credit: UN Photo/Loey Felipe

By Alon Ben-Meir
NEW YORK, Oct 16 2025 (IPS)

The ceasefire agreement and the release of Israeli hostages and Palestinian prisoners are only the first steps on the long and treacherous road that could end the calamitous, decades-long Israeli-Palestinian conflict. In my recent article, “A Rare Alignment:The World Stands Ready, Are the Palestinians?”

I tackled what the Palestinians must do to realize their national aspirations. In this article, I address what the Israelis must do not only to end their conflict with the Palestinians, but also to salvage Israel’s moral standing, which lies in ruin in Gaza.

The Israeli-Palestinian conflict has reached a new breaking point, more precipitous now than any time before. Although Israelis have experienced unfathomable trauma as a result of Hamas’ horrific attack, now is the time for all Israelis to carefully examine the circumstances that have brought them to this fateful crossroads.

Decades of violent conflict and the persistent denial of each other’s rights culminated in Hamas’ savagery, followed by the longest and most devastating war, which has reframed the nature of the conflict. It made it clearer than ever before that those who wrote the obituary for a two-state solution must now rewrite their script. As much as co-existence is inescapable, so is the inevitable rise of a Palestinian state.

Choosing the right path would require courage and a new vision. The Israelis must first disabuse themselves of several beliefs embedded in their psyche and push for a just solution to the conflict with the Palestinians, which is central to gradually restoring Israel’s shattered moral standing, which only the Israelis themselves can reclaim.

Existential Threat
The Israelis have been indoctrinated to believe that a Palestinian state would pose an existential threat and must be prevented at all costs, which has been falsely promulgated for decades by egocentric, nationalist and corrupt politicians like Netanyahu. At this juncture, the Israelis need to accept the irrevocable reality of Palestinian existence and take action to mitigate their fear rather than perpetuate enmity.

Israel was created as a sanctuary for any Jew who wishes to live in peace and security. This millennium-old dream however, cannot be realized, as time has shown, as long as the Palestinians are denied a state of their own.

The Israelis need to overcome their anxieties and misguided beliefs by finding meaning and self-affirmation, which does not hinge on denying the Palestinians their own state. They should step away from the deeply rooted, misguided fear that a Palestinian state indeed poses an existential threat, because without it, Israel renders itself permanently insecure, as time has shown.

Hatred Toward the Palestinians
The Israelis’ hatred of the Palestinians is rooted in a century-old conflict, which has only deepened due to the continuing acts of violence and the prevalence of mutually acrimonious narratives. This is further compounded by the Israelis’ belief that the Palestinians refuse to accept Israel’s right to exist. Instead of focusing on practical measures of reconciliation necessitated by the inescapable coexistence, they clung to hatred, which subconsciously justifies their continuing resistance to Palestinian statehood.

A well-known proverb notes that “Hatred is like drinking poison and expecting the other person to die.” Indeed, hatred is self-destructive, and letting go of it is essential for peaceful coexistence. The Israelis must live in the present to free themselves from the shackles of past prejudices against the Palestinians and reach out rather than shun them.

Such an approach may surprise many Israelis, who will find that generally the Palestinians are a willing partner eager to engage, albeit only if they believe they stand a good chance of realizing their national aspirations.

Refusing the Reality of Coexistence
The Israelis need to come to terms with the fact that accepting what cannot be changed and embracing it with understanding and even compassion would ultimately serve their own interests. In essence, Israelis must use their collective power to create the conditions that produce mutual political, economic, and security gains, which is the only way to coexist peacefully. Israelis must ask what the alternative to peaceful coexistence is.

Has anyone come up with a viable and mutually acceptable alternative whereby both can live in peace, short of a two-state solution?

The irony is that while Netanyahu spent decades trying to prevent the establishment of a Palestinian state, his devastating onslaught on the Palestinians has only produced precisely the opposite. It has rallied the international community to support an independent Palestinian state like never before.

Israel can annex all the West Bank and Gaza, assuming that it could live with international isolation, sanctions, expulsion from various international organizations, etc., but where will the Palestinians go?

For how long can seven million Israeli Jews suppress seven million Palestinians living in their midst and around them? How many Palestinians can they kill, displace, or starve to death? What choice would the Palestinians be left with other than armed struggle?

Since coexistence is inescapable, under what kind of an umbrella do the Israelis want to live? Hamas’ savagery and Israel’s devastating retaliation only attest to the consequences of decades-long mutual systematic dehumanization.

Unless the Israelis accept coexistence as an unmitigated reality, they will have to raise generations of warriors trained to kill Palestinians, destroy their properties, and live by the sword for as far as the eye can see.

The Catastrophic Loss of Israel’s Moral Standing
There are no words to describe the lasting damage that the Netanyahu government has inflicted on Israel as a country and the Israeli people. The whole world was astounded to see Jews, of all people, committing crimes against humanity in broad daylight beyond the capacity of any human being with a conscience to grasp.

Yes, the world applies a double standard when it comes to the Jews, and for good reason. The Jews have suffered for millennia from persecution, discrimination, and expulsion, culminating with the Holocaust, and are expected, because of their tragic experience, to uphold the sanctity of life.

And while the Jews have lived by and spread the values of caring, compassion, empathy, and altruism—values that have shielded them throughout their dispersion—the barbaric Netanyahu government has betrayed these tenets of Judaism. It has left Israel, and by tragic extension, Jews round the world, with no moral ground to stand on while precipitating the exponential rise of antisemitism.

It is hard to imagine how any Israeli government would desert these values and perpetrate this inconceivable cruelty and vengeance upon the Palestinians. The killing of tens of thousands of women, children, and the elderly, the bombing of hospitals and schools, and the deliberate starvation of a whole people as a weapon of war, sent shock waves throughout the world, bewildering friends and foes.

The countries that admired Israel for its incredible achievements in all walks of life are now looking at it as a pariah state that has lost its moral compass and its way.

My Plea to the Israelis—Facing a Moral Reckoning
No one can make light of the trauma and the horrendous suffering so many of you have and continue to endure because of Hamas’ butchery and heartless imprisonment of the hostages. But your government’s retaliatory war, which quickly became a war of revenge and retribution that killed tens of thousands of innocent civilians, did not do justice to your sacrifices by committing horrific war crimes in your name.

The war in Gaza and its consequences demand that Israel face a moral reckoning. You need to confront your government’s actions that plundered the depths of human immorality. Your moral obligation is to rise against Netanyahu’s government.

Remember, the Palestinians will recover from the catastrophe they have endured, rebuild their lives, and coalesce around a renewed effort, with the mounting support of the international community, to realize their aspiration for statehood.

Israel, however, has sustained a far greater catastrophe by forsaking Jewish values. It will take a generation (or more) before your country can regain a measure of moral standing, and that is only if it ends the conflict with the Palestinians in a fair and just way based on a two-state solution.

Now it’s time for accountability. Following the release of the hostages, you now need to embark on bringing an end to the Israeli-Palestinian conflict. Pour into the streets by the hundreds of thousands and demand the immediate resignation of Netanyahu and force him to face a commission of inquiry about his conduct before and after Hamas’ attack.

What you need to pursue now is building on the ceasefire and demanding that a newly-formed government move step-by-step toward implementing the Trump peace plan, which must culminate in establishing a Palestinian state.

This will not be a gift to the Palestinians. Rather, this is what you must do to transform the calamitous war in Gaza and the horrific pain, suffering, and losses you have sustained into a breakthrough on the road toward the long-awaited and desperately needed peaceful Israeli-Palestinian coexistence.

Dr. Alon Ben-Meir is a retired professor of international relations, most recently at the Center for Global Affairs at NYU. He taught courses on international negotiation and Middle Eastern studies.

IPS UN Bureau

 


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